ProductCategory: HumanAdenovirusType5(dE1/E3);Ad-CAG-GCaMP6f;Ad-CBA-GCaMP6f
Description:
GCaMPisageneticallyencodedcalciumindicator(GECI)andcreatedfromafusionofgreenfluorescentprotein(GFP),calmodulin(CaM),andM13,apeptidesequencefrommyosinlightchainkinase. WhenGECIbindsCa2+,theconformationalchangeofGCaMP inducesproximityofthe GFPparts,eliciting strongGFPfluorescencesignal,whichallowsmeasuringactionpotentialsandotherreceptoractivationeventsthattriggerCa2+influx.TheadvantageofGECI'sarethattheycanbegeneticallyspecifiedforstudiesinlivingorganisms.
GCaMP6isanovelultra-sensitiveformatofGCaMPthatoutperformedothersensorsintermsofaccuracyandsensitivityinmeasuringcytosolCa2+level. MutationsincalmodulinpartofGCaMP6createdseveralvariants whichshoweddifferentcalciumfluorescencedecayrate(fast- GCamP6f, slow -GCaMP6s andmedium-GCaMP6m).
Thisrecombinanthumanadenovirustype5expressesgeneticallyencodedcalciumindicatorGCaMP6funderCAGpromoter(alsoknownasCBApromoter).
Titer: 1x1010 ~1x1011 PFU/mL
StorageBuffer: DMEMwith2%BSA&2.5%Glycerol
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